CONNECT
Let science do the talking
STING
AGONIST
CRD3874-SI: a novel allosteric STING agonist with high systemic tolerability
Immunotherapy of Cancer Conference, Munich, Germany. 2024
The Society for Immunotherapy of Cancer (SITC), San Diego, USA, 2023
AACR Annual Meeting in New Orleans, Louisiana, USA, 2022
The discovery of potent small molecule cyclic urea activators of STING
Eur. J. Med. Chem.,2022
The discovery of potent small molecule activators of human STING
Eur. J. Med. Chem.,2020
G10 is a direct activator of human STING
PLOS One, 2020
CRD5500: A versatile small molecule STING agonist amenable to bioconjugation as an ADC
AACR Annual Meeting in Atlanta, GA, USA, 2019
Novel small-molecule human STING agonists generate robust Type I interferon responses in tumors
AACR conference on Tumor Immunology and Immunotherapy in Boston, MA, USA, 2017
CURADEV’S STING PATENTS
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WO 2018/234807
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WO 2018/234805
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WO 2018/234808
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WO 2019/243823
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WO 2019/243825
ACSS2 AND
THE STRESS RESPONSE
Small molecule ACSS2 inhibitors target acetate metabolizing tumor cells in hypoxic conditions
AACR (2018) Annual Meeting in Chicago. IL, USA, 2018
CURADEV’S ACSS2 PATENTS
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WO 2021/014415
TDO/IDO
AACR Annual Meeting in New Orleans, LA, USA, 2016
Novel inhibitors of human IDO1 and TDO
AACR’s Special Conference on Tumor Immunology and Immunotherapy held in Orlando, FL, USA, 2014
CURADEV’S TDO/IDO PATENTS
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WO 2014/186035
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WO 2014/141110
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WO 2016/027241
BLOOD BRAIN
BARRIER PENETRATION
Bioorganic & Medicinal Chemistry Letters, 2016
DUAL KINASE
INHIBITORS
NEUROSCIENCE
The immune-inflammatory response of oligodendrocytes in a murine model of preterm white matter injury: the role of TLR3 activation
Cell Death & Disease. 2021
Cell Metabolic Alterations due to Mcph1 Mutation in Microcephaly
Cell Reports, 2020
Cerebellum, 2020
Neuroinflammation in preterm babies and autism spectrum disorders
Pediatric Research, 2018
Cell Death & Differentiation, 2018
Cerebellum, 2018
STIL balancing primary microcephaly and cancer
Cell Death & Disease, 2018